Magnetic Separation – Simulations in Process Engineering
High-gradient magnetic fishing (HGMF) is a method for the downstream processing of biomolecules such as proteins. In the first step of this method magnetic particles are coated with a layer that contains specific ligands for a certain target molecule. The particles are then introduced into a medium containing the target molecule and these molecules adsorb to the ligands. The particles are then separated on a magnetized wire and transferred to another medium. Finally, an elution step follows, in which the purified molecules are recovered. The simulation shows the deposition of magnetic particles on a magnetized single wire and models the magnetic separation step of the HGMF process. Dipol forces of the particles are considered in a coupled DEM-LBM approach and realized within the open source softare OpenLB.
Simulation with OpenLB and Visualisation by Sascha Janz and Marie-Luise Maier
Contributed by Mathias J. Krause.